Serena, Illinois, is a small, unincorporated community and census-designated place in LaSalle County, known for its quiet rural charm and close-knit community. With a population of approximately 129 as of the 2020 census, Serena offers a peaceful escape with its picturesque countryside, ideal for outdoor activities like hiking and bird watching. The village, steeped in agricultural heritage since the mid-19th century, features a community center that hosts local gatherings and nearby farms that supply fresh produce. Serena is also home to the Serena Community Unit School District 2, which includes a high school, middle school, and elementary school, and is served by the Serena Fire Protection District. Its serene atmosphere and historical roots make it a quintessential slice of rural America.

Serena currently has 2 single family homes for sale with an average list price of $253,750. The average annual property tax for Serena is $4,788.73.